I used my iPhone for turn-by-turn directions because it was far superior to the navigation functionality built into my car. This ad could potentially have caused me to have to interact with my phone while driving to disable airplane mode and allow me to resume navigation.
No, it cannot cause that. You may illegally choose to then grab your phone while driving to fiddle with the settings, but that is your own reckless and negligent choice.
It may definitely cause you to drive around in unknown area while trying to figure out where you can stop to turn the navigation back on. If you're on a motorway, that may be an additional 20+ miles until you can stop safely.
If it happens to kill your navigation, it's going to cause a lot of unnecessary distraction. Whether you decide to turn it on again while driving or wait until you can stop.
I don't think it's illegal to manipulate your phone while driving anywhere I've lived, though it was illegal to text or talk without using a hands-free device.