I'll echo this - I was at a point where I was starting to miss work because I had so much wrist pain that I couldn't type, and then I switched to a Kinesis. A month later I was back up to full speed and haven't had any pain since. I don't know how it stacks up against competitors, but the thing quite literally saved my wrists, I highly recommend trying it if you're having trouble.

Definitely has a bit of a learning curve, though, for a few weeks I had trouble remembering which keys were where.