My experience so far has been that the knowledge of what should and shouldn't be, while important, bears no predictive power whatsoever as to what actually ends up happening.
In this instance, in particular, I wouldn't expect our preferences to bear any relevance.
> knowledge of what should and shouldn't be, while important, bears no predictive power whatsoever as to what actually ends up happening.
I don’t know if you are intentionally being vague and existential here. However, context matters, and the predictive power is zero sounds unreasonable in the face of history.
I think humans learning that diseases were affecting us and thus leading to solutions like antibiotics and vaccines. It was not guaranteed, but I’m skeptical of the predictive power being zero.
In this instance, in particular, I wouldn't expect our preferences to bear any relevance.