I recently installed NT4 (including Plus!) in an emulator with a VESA video driver, and was greatly surprised when about half of the icons that I thought of as “Windows 2000” (including the memorable “My Computer” one with the bulbous sky-blue screen) turned out to be available even there, provided a non-indexed mode. The rest were the more familliar 16-color-compatible 95/NT4 ones, making for an incongruous result overall. I guess what I want to say is that 16-color compatibility is a large part of the 95/NT4 look from which 2000 very carefully departed.
To be frank, I wasn't aware such a mode was a thing, but it makes sense.