Interesting! how does that work though? I thought reduced sugar craving was part of how GLP-1s aid in weight loss as the paitent craves sugar less and thus eats less.
I'm not a biochemist, so I can't say with any authority, but presumably its to do with the 3rd antagonist and its impact on glucagon. Most of what I have heard is through Reddit communities for the on-market drugs (1st and 2nd gen peptides). The anecdotes from Retatrutide sound like it has way less impact on appetite and for some people that's actually a downside even though the weight loss effects appears to be significantly more powerful.
