Agreed. An example of 2 is colchicine, thought to be the oldest drug still in use. It's an ancient Greek flower remedy, and the standard treatment for gout flares. It has long been known to be very effective, and also toxic. It was only in the past couple of decades that a formal trial was done in the USA, based on some legislation which gave the company a monopoly on the drug - which is now fantastically expensive in the USA. Elsewhere it costs pennies.