Yes. Most user applications have been updated but plenty of libraries have not been.
Most of the python packages that have significant C deps often have issues compiling (e.g. Scipy, igraph, etc). It's almost always possible to work around these issues but it gets tiring since it's compounded with the usual macOS breaking changes every year. Any binary compiled with AVX-512 instructions (e.g. Tensorflow, MuJoCo, etc.) will also need to be recompiled.
So tl;dr most (but far from all) popular closed source programs have been updated/recompiled for ARM (or at least run decently with Rosetta), but many libraries/open-source projects require some painful recompiling.
Most of the python packages that have significant C deps often have issues compiling (e.g. Scipy, igraph, etc). It's almost always possible to work around these issues but it gets tiring since it's compounded with the usual macOS breaking changes every year. Any binary compiled with AVX-512 instructions (e.g. Tensorflow, MuJoCo, etc.) will also need to be recompiled.
So tl;dr most (but far from all) popular closed source programs have been updated/recompiled for ARM (or at least run decently with Rosetta), but many libraries/open-source projects require some painful recompiling.