It depends. There are different types of cities in the US. In general, if we're talking about suburbs, there are businesses but they are usually all centered at the same place. Usually referred to as the city center. This can be a smaller or big center, depending on the town. Then there are towns that have those big shopping plazas you usually have to drive to. The city center concept is much nicer in my opinion.
Businesses also tend to line the major roads (or at least be clustered at major intersections) whether it's city or suburb. And suburbs are apparently planned to have major roads running through them with fairly regular spacing.
