AlphaFold not only depended on a great deal of domain knowledge, it actually used one of the most famous physics-based methods. The only people who think that AlphaGo was made by a bunch of noob AI guys with a neural network are the people who don’t know anything about it.
I said relatively, they certainly had less domain knowledge than the competing teams. I have always been a strong proponent of combining ML and NNs with traditional methods.
