I had the realization a while back that certain advertisers were flooding my Newsfeed with Sponsored posts every time I interacted with them in some way -- on or off Facebook. So I started regularly clearing out the Interests and Advertisers sections of Ad Preferences and now my Newsfeed is almost entirely devoid of Sponsored posts.

The experience using Facebook without them exploiting knowledge of my "preferences" is substantially better.

Granted, I'm running ad blockers, so most of the low-value advertising on FB was already blocked.