Lying on the floor of a club curled up drooling all over yourself in a dissociated state doesn't sound very appealing to me. I'd keep that for controllable environments.

I thought you're not supposed to mix uppers and downers..

You are not supposed to mix uppers and downers.

This is because it increases the danger of drug use and could cause death. But no one has ever said not to mix uppers and downers because it wasn't fun.