I've since read TFA, as well as many other articles, official correspondence, and case law around the issue. I understand that without the additional ingredients of SNAC/sodium caprate/sodium caprylate, the bioavailability is probably too low to have a clinical effect at oral doses <15mg/day.
I read the actual FDA referral to the DOJ. They don't mention anything about any of what this article touches on. It's not clear that the referral makes correct claims about anything illegal going on. In statements, the FDA says that compounding pharmacies "cannot state compounded drugs use the same active ingredient as the FDA-approved drugs". That's a very brand-new interpretation of rules, and might not stand up to judicial scrutiny. In the context of "shouldn't investors have known that Hims business model is illegal??" -- it makes sense that investors couldn't have known ahead of time that the FDA would claim this.
i haven't read the article. is the question, can hims ship a clone of 25mg oral wegovy? yes, it can.
> ... at oral doses <15mg/day.
well it's not a clone of rybelsus, it's a clone of wegovy 25mg. so i suppose it will be bioavailable at 25mg.
> That's a very brand-new interpretation of rules
this is true. Tidmarsh, the whole Novo Nordisk deal with Trump, it's now about, well we'll do the patent enforcement we didn't want to do before. The simple fact of the matter is, these are lifestyle products, so it's not so black and white if they ought to have the same patent and payment protections as typical therapeutics.
The main point of lockdown mode is to provide security against state sponsored attacks against journalists. If it was granular the attackers would exploit whichever switches most people leave off. It would be a cat/mouse game until all the switches were turned on. So Apple skipped to the end of the game.
I think they have a point about merging the CPU & memory. It seems to have worked out well for Apple. Their proposal sounds like another step in the same direction.
Internal combustion engines are actually more efficient in cold weather than hot weather. But the other factors like drag outweigh the increased efficiency of the engine. And since gas engines are so inefficient to begin with you don't notice much of a difference. https://physics.stackexchange.com/questions/270072/heated-an...
"...there's no point to working with other people because you can't predict their behavior exactly."
Because you CAN predict coworker behavior to a useful point. Ex, they'll probably reply to that email on Monday. They'll probably show you a video that you find less amusing than they do.
With LLMs you can't be quite sure whether they will make something up, forget a key detail, hide a mistake that will obviously be found out when everything breaks, etc. Stupid things that most employable people wouldn't do, like building a car and forgetting the wheels.
Tbh I don’t think people outside the HN crowd would think it’s that crazy to use ChatGPT. It feels like the kind of thing everyone does regardless of the rules, like driving 10mph over the speed limit.
You are on a website called HackerNews, where people are encouraged to comment on articles or "posts". You are seeing this because you are looking at the comment section of one such post.
Will your AI Teammate hit the penjamin with you in the parking lot? We need to engineer AI that can replicate the necessary prerequisites to understanding what makes a good bagel good in the first place. Otherwise they might waste money on low quality bagels, or just generally have no chill, and that is unacceptable.
They’re a joke, I used to have one in my car and the combination of sunlight & internally produced heat would make my phone shut off & display a “iPhone is too hot” message. Even when it’s cold outside.
I switched to wired charging with the phone mounted in the same spot and the heat issue went away. Wireless charging produces a lot more heat than wired.
That's really quite interesting. I know the wireless charging uses more power to deliver less power, so there's heat generation due to the loss of power in the transfer (I'm assuming that's how it works).
But, I figured that the battery would heat up more the faster it's being charged, and so wired charging at the same wattage would heat the battery more than wireless charging.
Must be a lot of power->heat transfer loss with wireless charging.
These acronyms are a nightmare, what the hell is a PHEV? EREV? PZEV?
Consumers are just expected to know this stuff somehow, it’s nuts. Sometimes I buy parts for my car and just hope I selected the right one, because some models are PZEV/not PZEV but the sticker that would tell me has turned completely white & can’t be read.
> These acronyms are a nightmare, what the hell is a PHEV? EREV? PZEV?
PHEV is the old term, it's a plug in hybrid EV. I.e., you can plug it in and use the battery, or use the ICE engine via petrol (gasoline).
(B)EVs are pure battery EVs. Think Tesla.
REEV/EREV is range extender EV. Essentially an EV that has a small ICE engine that's very handy for making the 50 or 100km battery "run" for 500km if the need arises, by using the ICE as a generator.
In some countries, you also have "strong" and "weak" hybrids - these are not cars you can plug in (they only take petrol), but they use some motors and battery to vastly improve the efficiency of the engine. Think doubling your mileage levels of good.
> Consumers are just expected to know this stuff somehow, it’s nuts.
Yeah no I don't think that's good design either. May I ask what kind of parts do you buy that makes it so confusing? Our car (Honda) has a very simple model name, there's not a lot of variations or options to confuse to begin with.
Btw, if you want a real fun doozy, look up the parallel series hybrid system that iirc GM had. It was a beautiful beast - it could basically take any power source, and do anything with it (charge battery, run wheels etc).
There's a good YouTube video on it if you search for it.
Whenever I buy parts for my regular gas car the parts site asks if it’s PZEV or DOHC. To make matters worse the PZEV version is also DOHC (dual over head cams) as far as I can tell. And the VIN number doesn’t say if it’s PZEV or not. It’s not on any of the paperwork I got with the car either.
I googled PZEV, and apparently all it means is that it isn't releasing gasoline vapours - other emissions don't matter.
So it's essentially just an ICE engine car that's not super polluting. It has nothing to do with EVs apart from being misleading in its name (perhaps on purpose?).
I don’t think that sounds right. My car was never offered with start/stop tech. Unless maybe they ask regardless of whether the car could even have that option… hmm.
Consumers just take their shit to the dealer which hires technicians who job it is, literally, to know "what the hell". If that is too complicated for you to figure out, I can't recommend you do your own work on your car.
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