Feature request - a way to filter by age / difficulty from the home page. I see it on individual pages but didn’t quickly see the age listed as a tag. This is a point of friction on most coloring page sites. Congrats on this. I have bookmarked it. Thank you
For others who stumble upon this, another good free site without too many ads:
Then started considering a vanilla eMacs. I started taking notes on packages I found highly recommended and interesting.
Then I found this. And the author has done all that work and then made it into a “let me walk through a config” including a lot of the most recommended packages and sensible configs.
Gives you the lesson of building a config, knowing what’s in your config, and then being fluent in changing it.
For the many posters recommending BPA free paper - does anyone have suggestions / a link for a reliable seller?
I looked on Amazon after another receipt printer post on HN but couldn’t find anything that provided confidence in the BPA characterization. ULINE is quantities are absurd for personal use. Imagine their most be a decent alternative but never see any named.
Xenodium is doing amazing things for emacs. If you enjoy this or are generally emacs interested, I’d check out his blog @ https://xenodium.com/
I also purchased my first iOS app upon recommendation from other emacs users - the author’s app, Journelly. A simple portable place to save down links or notes and export out as org files (as one option; apparently markdown is on the way). https://xenodium.com/journelly-for-ios
No affiliation to Xenodium. I’ve just been diving into emacs this year and love seeing his contributions.
I have just spent a few days (part time) getting AiderEmacs working for running local models and commercial APIs. Fairly useful.
Next up for me is integrating your agent-shell with Gemini in my Emacs workflow. I will let you know how that goes and any other feedback I think might be useful.
EDIT: just finished a 20 minute Emacs session using agent-shell - love it!
Potentially inhibiting IL-6 or reducing Lp(a). We'll get an early glimpse from some robust Phase 3's next year. These have been in the works for several years with tens of thousands of patients enrolled - it'll be an exciting set of readouts.
Novo Nordisk purchased Corvidia Therapeutics in 2020 [1] for their IL-6 antibody and will read out the first of three Phase 3's in 2026 [2]. Their programs, however, are focused on individuals with higher risk factors like chronic kidney disease (2026 topline), a couple kinds of heart failure (2027), and a prior myocardial infarction (heart attack; 2027). These trials notably are on top of "standard of care" existing therapies, so they're looking for additional benefit beyond what is commonly sought, like LDL reduction (highlighted in other comments).
Novartis recently announced an intended acquisition of Tourmaline Bio for their IL-6 antibody [3]. So attention to the biological target is heating up.
Another target mentioned in the comments is Lp(a). Genetic studies suggest a heightened risk of cardiovascular disease. Therapeutics aimed at reducing Lp(a) levels are being explored separate from IL-6 for a similar end goal of avoiding cardiovascular events (i.e. heart attacks, death).
Novartis will read out a Phase 3 of an Lp(a) reducing therapeutic in the first half of 2026 [4]. Amgen will likely read out theirs likely sometime thereafter [5]. These have been a long time coming: Amgen in-licensed their asset from Arrowhead in 2016 [6], Novartis in-licensed their asset from Ionis/Akcea in 2017 [7].
If any of these work, there's a chance that they'd be explored in patients with less pronounced risk than the original studies in these Phase 3's. Amgen has already announced an intent to explore their Lp(a) drug in a Phase 3 with participants with elevated Lp(a) at "high risk" for a first cardiovascular event in 2H25/1H26.
I've stuck with it so far (over 3 years in). I've learned a few Emacs-isms (M-x is indispensable) but it's pretty convenient to press space and be presented with a list of choices if I've forgotten certain key bindings.
I'm unlikely to give up evil with ~25 years of Vi/Vim muscle memory, but I'm open to trying other systems in the future. Since Vi/Vim operations are verb -> object, the advantages of object -> verb commands are tempting so one can see the target of a command before it's actual execution. The Vim workaround is invoking visual mode, of course.
Obviously with vanilla Vim, you're going to have to memorize everything and I eventually did that way back when. Being presented with the key bindings menu helps to remind me of things that I use less frequently and avoids time spent digging into the help system.
Sorry for the slow reply (but then my HN replies are never guaranteed either).
Correct. And confirmed by Kodak on their Facebook page. The “going concern” disclosure is an accounting requirement. However, the company claims to have line of sight toward addressing it.
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