One of the big strengths of Fable is that it can easily work with existing TypeScript bindings. ts2fable allows you to convert a TypeScript binding to be used with Fable, which allows you to leverage that mindshare easily.
I was/am worried about the type gymnastics the TypeScript team has done to support in the wild code not being compatible with systems like scalajs and Fable(F#). Giving it another look now though, it's pretty promising seeing that Alfonso has implemented erased union types and even opened an issue to have them added to F# :)